原著論文

2023年

The NERP-4-SNAT2 axis regulates pancreatic β-cell maintenance and function. 　Pubmed

Zhang W, Miura A, Abu Saleh MM, Shimizu K, Mita Y, Tanida R, Hirako S, Shioda S, Gmyr V, Kerr-Conte J, Pattou F, Jin C, Kanai Y, Sasaki K, Minamino N, Sakoda H, Nakazato M. Nat Commun. 2023 Dec 9;14(1):8158. doi: 10.1038/s41467-023-43976-8.

An efficient selenium transport pathway of selenoprotein P utilizing a high-affinity ApoER2 receptor variant and being independent of selenocysteine lyase. Pubmed

Mizuno A, Toyama T, Ichikawa A, Sakai N, Yoshioka Y, Nishito Y, Toga R, Amesaka H, Kaneko T, Arisawa K, Tsutsumi R, Mita Y, Tanaka SI, Noguchi N, Saito Y. J Biol Chem. 2023 Aug;299(8):105009. doi: 10.1016/j.jbc.2023.105009. Epub 2023 Jul 3.

Association of COVID-19 information media, providers, and content with vaccine uptake among Tokyo residents. Pubmed

Noguchi N, Yokoi R, Masu T, Watanabe M, Itoh S, Yumoto S. Vaccine X. 2023 Nov 19;15:100411. doi: 10.1016/j.jvacx.2023.100411. eCollection 2023 Dec.PMID: 38161990 

Antioxidant action of persulfides and polysulfides against free radical-mediated lipid peroxidation. https://doi.org/10.1080/10715762.2023.2165918

T. Kaneko, Y. Mita, K. Nozawa-Kumada, M. Yazaki, M. Arisawa, E. Niki, N. Noguchi, and Y. Saito Free Radic. Res. 56(9-10):677-690, 2023. 

2022年

a-Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of endoplasmic reticulum membrane disruption. Pubmed

R. Chiba, Y. Urano, and N. Noguchi Steroid, vol. 189, 2023, https://doi.org/10.1016/j.steroids.2022.109136

Suppression of Amyloid-β Adsorption on Endoplasmic Reticulum Stress-Mimicking Membranes by α-Tocopherol and α-Tocotrienol. Pubmed

Y. Nakatani, N. Shimokawa, Y. Urano, N. Noguchi, and M. Takagi The Journal of Physical Chemistry Letters, pp. 11955–11960, 2022.

Integrated stress response is involved in the 24 (S)-hydroxycholesterol-induced unconventional cell death mechanism. Pubmed

Y. Urano, S. Osaki, R. Chiba, and N. Noguchi Cell Death Discovery, vol. 8, no. 406, 2022, https://doi.org/10.1038/s41420-022-01197-w

Redox-sensitive DJ-1 protein: An insight into physiological roles, secretion, and therapeutic target.

https://doi.org/10.1530/REM-22-0007

Biplab K. Dash, Yasuomi Urano, Yoshiro Saito, Noriko Noguchi Redox. Exper. Med. 1, 95-115, 2022

Role of selenoprotein P expression in the function of pancreatic b cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation. Pubmed

Nanako Kitabayashi, Shohei Nakao, Yuichiro Mita, Kotoko Arisawa, Takayuki Hoshi, Takashi Toyama, Kiyo-aki Ishii, Toshinari Takamura, Noriko Noguchi, Yoshiro Saito Free Radic Biol Med. 9-103 2022

2021年

Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis.

Hajime Kato, Hiroyasu Sato, Michiaki Okuda, Jun Wu, Shingo Koyama, Yasuhiko Izumi, Tomonori Waku, Mitsuyoshi Iino, Masashi Aoki, Shigeki Arawaka, Yasuyuki Ohta, Kenichi Ishizawa, Kanan Kawasaki, Yasuomi Urano, Tomohiro Miyasaka, Noriko Noguchi, Toshiaki Kume, Akinori Akaike, Hachiro Sugimoto, Takeo Kato Amyotroph Lateral Scler Frontotemporal Degener, 1-7, 2021

NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition.

Tsuyoshi Waku, Toru Hagiwara, Natsuko Tamura, Yuri Atsumi, Yasuomi Urano, Mikiko Suzuki, Takuya Iwami, Katsuya Sato, Masayuki Yamamoto, Noriko Noguchi, Akira Kobayashi iScience, 24, e103180, 2021

Different functions of vitamin E homologues in the various types of cell death induced by oxysterols.

Atsuki Suzuki, Yasuomi Urano, Tomohisa Ishida, Noriko Noguchi, Free Radic Biol Med. 176, 356-365, 2021, https://doi.org/10.1016/j.freeradbiomed.2021.10.008

Identification of a novel endogenous long non-coding RNA that inhibits selenoprotein P translation.

Yuichiro Mita, Risa Uchida, Sayuri Yasuhara, Kohei Kishi, Takayuki Hoshi, Yoshitaka Matsuo, Tadashi Yokooji, Yoshino Shirakawa, Takashi Toyama, Yasuomi Urano, Toshifumi Inada, Noriko Noguchi, Yoshiro Saito. Nucleic Acids Res. Jun 18, 2021

2020年

Antioxidant action of vitamin E in vivo as assessed from its reaction products with multiple biological oxidants.

Etsuo Niki, Noriko Noguchi Free Radic Res, 1-33, 2020

Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis.

Miku Kazama, Yoichiro Kato, Akiyoshi Kakita, Noriko Noguchi, Yasuomi Urano, Kenta Masui, Motoko Niida-Kawaguchi, Tomoko Yamamoto, Kazuhiko Watabe, Kazuo Kitagawa, Noriyuki Shibata Neuropathology, 40, 587-598, 2020

Souble iron accumulateon induces microglial glutamate release in the spinal coed of sporadic amyotrophic lateral sclerosis.

Motoko Niida-Kawaguchi, Akiyoshi Kakita, Noriko Noguchi, Miku Kazama, Kenta Masui, Yoichiro Kato, Tomoko Yamamoto, Tatsuo Sawada, Kazuo Kitagawa, Kazuhiko Watabe K, Noriyuki Shibata Neuropathology. 40, 152-166, 2020

Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation.

Yasuomi Urano, Mina Takahachi, Ryo Higashiura, Hitomi Fujiwara, Satoru Funamoto, So Imai, Eugene Futai, Michiaki Okuda, Hachiro Sugimoto, Noriko Noguchi Cells. 9, 349, 2020

2019年

Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents.

Md Nurul Islam, Yuichiro Mita, Keisuke Maruyama, Ryota Tanida, Weidong Zhang, Hideyuki Sakoda, Masamitsu Nakazato

J Endocrinol. 244, 13-23, 2019

Brain targeting of acyl CoA:cholesterol O-acyltransferase-1 inhibitor, K-604, via the intranasal route using a hydroxylcarboxylic acid souktion.

Kimiyuki Shibuya, Shigeru Morikawa, Masayoshi Miyamoto, Shin-ichi Ogawa, Yoshihiko Tsunenari, Yasuomi Urano, Noriko Noguchi ACS Omega, 4,16943-16955, 2019

24(S)-Hydroxycholesterol induces ER dysfunction-mediated unconventionall cell death.

Yasuomi Urano, Diep-Khanh Ho Vo, Hirofumi Araki, Noriko Noguchi Cell Death Discov. 5,113, 2019

Polymerization of oxidized DJ-1 via noncovalent and covalent binding: Significance of disulfide bond formation.

Mayuka Kobayashi, Kana Muramatsu, Takamitsu Haruyama, Haruka Uesugi, Ai Kikuchi, Hiroki Konno, Noriko Noguchi, Yoshiro Saito ACS Omega, 4, 9603-9614, 2019

2018年

6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.

Yasuomi Urano, Chinatsu Mori, Ayano Fuji, Keito Konno, Takayuki Yamamoto, Shohei Yashirogi, Mayu Ando, Yoshiro Saito, Noriko Noguchi Autophagy, 14,1943-1958, 2018

Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation.

Yuki Kimura, Minori Asa, Yasuomi Urano, Yoshiro Saito, Kiyotaka Nishikawa, Noriko Noguchi Biochimie, 153, 203-209, 2018

Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin.

Yuichiro Mita, Yuto Kataoka, Yoshiro Saito, Takuma Kashi, Kojiro Hayashi, Asa Iwasaki, Takanori Imanishi, Tomohiro Miyasaka, Noriko Noguchi Scientific Reports, 8, 12056, 2018

Hydrogen peroxide-reducing factor released by PC12D cells increases cell tolerance against oxidative stress.

Asami Muraishi, Emi Haneta, Yoshiro Saito, Yutaka Hitomi, Mamoru Sano, Noriko Noguchi Biol Pharm Bull, 41, 777-785, 2018

Comparison of human selenoprotein P determinants in serum between our original methods and commercially available kits.

Yoshiro Saito, Hirofumi Misu, Hiroaki Takayama, Shin-ichiro Takashima, Soichiro Usui, Masayuki Takamura, Shuichi Kaneko, Toshinari Takamura, Noriko Noguchi Biol Pharm Bull, 41, 828-832, 2018

Diagnosis of Parkinson's disease and the level of oxidized DJ-1 protein.

Yuko Yamagishi, Kazumasa Saigoh, Yoshiro Saito, Ikuko Ogawa, Yoshiyuki Mitsui, Yoshiyuki Hamada, Makoto Samukawa, Hidekazu Suzuki, Motoi Kuwahara, Makito Hirano, Noriko Noguchi, Susumu Kusunoki Neuroscience Research, 128, 58-62, 2018

2017年

The pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy.

Kentaro Shimasaki, Miho Watanabe-Takahashi, Masato Umeda, Satoru Funamoto, Yoshiro Saito, Noriko Noguchi, Keigo Kumagai, Kentaro Hanada, Fujiko Tsukahara, Yoshiro Maru, Norihito Shibata, Mikihiko Naito, Kiyotaka Nishikawa Gene to Cells, 23, 22-34, 2017

Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models.

Yuichiro Mita, Kaho Nakayama, Shogo Inari, Yukina Nishito, Yuya Yoshioka, Naoko Sakai, Kanade Sotani, Takahiro Nagamura, Yuki Kuzuhara, Kumi Inagaki, Miki Iwasaki, Hirofumi Misu, Masaya Ikegawa, Toshinari Takamura, Noriko Noguchi, Yoshiro Saito Nature Communications, 8, 1658, 2017

Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of ROS and AMPK in muscle.

Hirofumi Misu, Hiroaki Takayama, Yoshiro Saito, Yuichiro Mita, Akihiro Kikuchi, Kiyoaki Ishii, Keita Chikamoto, Takehiro Kanamori, Natsumi Tajima, Fei LanLan, Yumie Takeshita, Masao Honda, Mutsumi Tanaka, Seiji Kato, Naoto Matsuyama, Yuya Yoshioka, Kaito Iwayama, Kumpei Tokuyama, Nobuhiko Akazawa, Seiji Maeda, Kazuhiro Takekoshi, Seiichi Matsugo, Noriko Noguchi, Shuichi Kaneko, Toshinari Takamura Nature Med, 23, 508-516, 2017

Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis.

Takaya Nakazawa, Yuta Miyanoki, Yasuomi Urano, Madoka Uehara, Yoshiro Saito, Noriko Noguchi J. Steroid Biochem. Mol. Biol., 169, 69-76, 2017.

Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox.

Bharatwaj Sowrirajan, Yoshiro Saito, Deepak Poudyal, Qian Chen, Hongyan Sui, Suk See DeRavin, Hiromi Imamichi, Toyotaka Sato, Douglas B. Kuhns, Noriko Noguchi, Harry L. Malech, H. Clifford Lane, Tomozumi Imamichi Sci. Rep, 7, 43441, 2017

Decrease of amyloid-b levels by curcumin derivative via modulation of amyloid-b protein precursor trafficking.

Rina Kotani, Yasuomi Urano, Hachiro Sugimoto, Noriko Noguchi J. Alzheimer’s Disease, 56, 529-542, 2017.

2016年

Esterification of 24(S)-hydroxycholesterol induces formation of atypical lipid droplet-like structure leading to neuronal cell death.

Wakako Takabe, Yasuomi Urano , Diep-Khanh Ho Vo, Kimiyuki Shibuya , Tanno M., Hiroaki Kitagishi, Toyoshi Fujimoto, Noriko Noguchi J. Lipid Res. 57, 2005-2014, 2016

Oxidized Lipoprotein as a Major Vessel Cell Proliferator in Oxidized Human Serum.

Yoshiro Saito, Noriko Noguchi PLoS One. 11 :e0160530, 2016

Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s desease patients.

Saito Y, Akazawa-Ogawa Y, Matsumura A, Saigoh K, Itoh S, Sutou K, Kobayashi M, Mita Y, Shichiri M, Hisahara S, Hara Y, Fujimura H, Takamatsu H, Hagihara Y, Yoshida Y, Hamakubo T, Kusunoki S, Shimohama S, Noguchi N Sci Rep.6:30793, 2016

Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death.

Kimiyuki Shibuya, Toshiaki Watanabe, Yasuomi Urano, Wakako Takabe, Noriko Noguchi, Hiroaki Kitagishi Bioorgan. Med. Chem, 24, 2559-2566, 2016

Development of a sol particle homogeneous immunoassay for measuring full-length selenoprotein P in human serum.

Mutsumi Tanaka, Yoshiro Saito, Hirofumi Misu, Seiji Kato, Yuki Kita, Yumie Takeshita, Takehiro Kanamori, Toru Nagano, Masatoshi Nakagen, Takeshi Urabe, Toshinari Takamura, Shuichi Kaneko, Kazuhiko Takahashi, and Naoto Matsuyama J. Clin. Lab. Anal., 30, 114-122, 2016

2015年

The protective role of DJ-1 in ultraviolet-induced damage of human skin: DJ-1 levels in the stratum corneum as an indicator of antioxidative defense.

Shioji Ishiwatari, Minako Takahashi, Chie Yasuda, Maho Nakagawa, Tatsuya Kon, Yoshiro Saito, Noriko Noguchi, and Shoko Matsukuma Arch. Dermatol. Res. 307, 925-935, 2015.

New aspects of 24S-hydroxycholesterol in modulating neuronal cell death

Noriko Noguchi, Yasuomi Urano, Wakako Takabe, and Yoshiro Saito Free Radic. Biol. Med., 87, 366-372, 2015

Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene.

Yoshiro Saito, Mototada Shichiri, Takashi Hamajima, Noriko Ishida, Yuichiro Mita, Shohei Nakao, Yoshihisa Hagihara, Yasukazu Yoshida, Kazuhiko Takahashi, Etsuo Niki, and Noriko Noguchi J. Lipid Res., 56, 2172-82, 2015

Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells.

Mayuko Morita, Azusa Sekine, Yasuomi Urano, Taki Nishimura, Wakako Takabe, Hiroyuki Arai, Takao Hamakubo, Tatsuhiko Kodama, and Noriko Noguchi J. Biochem. 158, 331-338, 2015

Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile.

Takeshi Kumagai, Hiroko Usami, Nao Matsukawa, Fumie Nakashima, Miho Chikazawa, Takahiro Shibata, Noriko Noguchi, and Koji Uchida Redox Biol., 4, 74-86, 2015

24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8.

Diep-Khanh Ho Vo, Yasuomi Urano, Wakako Takabe, Yoshiro Saito, and Noriko Noguchi Steroids, 99, 230-237, 2015

Aß induces oxidative stress in senescence-accelerated (SAMP8) mice.

Kurara Takagane, Jun Nojima, Hiroaki Mitsuhashi, Satoshi Suo, Dai Yanagihara, Fumio Takaiwa, Yasuomi Urano, Noriko Noguchi, and Shoichi Ishiura Biosci. Biotech. Biochem, 23, 1-7, 2015

2014年

Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.

Kazuhide Ishikura, Hirofumi Misu, Masafumi Kumazaki, Hiroaki Takayama, Naoto Matsuzawa-Nagata, Natsumi Tajima, Keita Chikamoto, Fei Lan, Hitoshi Ando, Tsuguhito Ota, Masaru Sakurai, Yumie Takeshita, Kenichiro Kato, Akio Fujimura, Ken-ichi Miyamoto, Yoshiro Saito, Satomi Kameo, Yasuo Okamoto, Yoh Takuwa, Kazuhiko Takahashi, Hiroyasu Kidoya, Nobuyuki Takakura, Shuichi Kaneko, and Toshinari Takamura Diabetologia, 57, 1968-1976, 2014

Immunostaining of oxidized DJ-1 in human and mouse brain.

Yoshiro Saito, Tomohiro Miyasaka, Hiroyuki Hatsuta, Kazuko Takahashi-Niki, Kojiro Hayashi, Yuichiro Mita, Osamu Kusano-Arai, Hiroko Iwanari, Hiroyoshi Ariga, Takao Hamakubo, Yasukazu Yoshida, Etsuo Niki, Shigeo Murayama, Yasuo Ihara, and Noriko Noguchi J Neuropathol Exp Neurol, 73, 714-728, 2014

The significance of oxidized DJ-1 protein (oxDJ-1) as a biomarker for Parkinson's disease.

Ikuko Ogawa, Yoshiro Saito, Kazumasa Saigoh, Yoshie Hosoi, Yoshiyuki Mitsui, Noriko Noguchi, and Susumu Kusunoki Brain Nerve, 66, 471-477, 2014

Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase1

Kazunori Yamanaka, Yasuomi Urano, Wakako Takabe, Yoshiro Saito, and Noriko Noguchi Cell Death Dis, 5, e990, 2014

Metformin Suppresses Expression of the Selenoprotein P gene via an AMPK-FoxO3a Pathway in H4IIEC3 Hepatocytes.

Hiroaki Takayama, Hirofumi Misu, Hisakazu Iwama, Keita Chikamoto, Yoshiro Saito, Koji Murao, Atsushi Teraguchi, Fei Lan, Akihiro Kikuchi, Reina Saito, Natsumi Tajima, Takayoshi Shirasaki, Seiichi Matsugo, Ken-ichi Miyamoto, Shuichi Kaneko, and Toshinari Takamura J Biol Chem, 289, 335-45, 2014

LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance.

Fei Lan, Hirofumi Misu, Keita Chikamoto, Hiroaki Takayama, Akihiro Kikuchi, Kensuke Mohri, Noboru Takata, Hiroto Hayashi, Naoto Matsuzawa-Nagata, Yumie Takeshita, Hiroyo Noda, Yukako Matsumoto, Tsuguhito Ota, Toru Nagano, Masatoshi Nakagen, Ken-ichi Miyamoto, Kanako Takatsuki, Toru Seo, Kaito Iwayama, Kunpei Tokuyama, Seiichi Matsugo, Hong Tang, Yoshiro Saito, Satoshi Yamagoe, Shuichi Kaneko, and Toshinari Takamura Diabetes, 63, 1649-64, 2014

2013年

Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death

Akishi Okabe, Yasuomi Urano, Sayoko Itoh, Naoto Suda, Rina Kotani, Yuki Nishimura, Yoshiro Saito, and Noriko Noguchi Redox Biol, 2, 28-35, 2013

Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain

Harumi Harada, Eiji Warabi, Taizo Matsuki, Toru Yanagawa, Kosuke Okada, Junya Uwayama, Akira Ikeda, Kazuhiro Nakaso, Kyoko Kirii, Noriko Noguchi, Hiroki Bukawa, Richard Siow, Giovanni Mann, Junichi Shoda, Tetsuro Ishii, and Takeshi Sakurai J Neurosci, 33, 14767-14777, 2013

Suppression of amyloid-b production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking

Yasuomi Urano, Sachika Ochiai, and Noriko Noguchi FASEB J, 27, 4305-4315, 2013

Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner

Izumi Kato, Hiroshi Maita, Kazuko Takahashi-Niki,, Yoshiro Saito, Noriko Noguchi, Sanae M.M.Iguchi-Ariga, and Hiroyoshi Ariga Mol Cell Biol, 33, 340-359, 2013

Serum selenium and selenoprotein P in patients with silicosis

Basilua Andre Muzembo, Narongpon Dumavibhat, N’landu Roger Ngatu, Masamitsu Eitoku, Ryoji Hirota, Shinichi Kondo, Yoji Deguchi, Yoshiro Saito, Kazuhiko Takahashi, and Narufumi Suganuma J Trace Elem Med Biol, 27, 40-44, 2013.

2012年

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation

Nobuhiko Harada, Koichi Ito, Tomonori Hosoya, Junsei Mimura, Atsushi Maruyama, Noriko Noguchi, Kenichi Yagami, Naoki Morito, Satoru Takahashi, Jon M. Maher, Masayuki Yamamoto, and Ken Itoh Free Radic Biol Med, 53, 2256-2262, 2012

Enhanced CD36 expression changes the role of Nrf2 activation from anti-atherogenic to pro-atherogenic in apoE-deficient mice

Hirotaka Sawada, Yoshiro Saito, and Noriko Noguchi Atherosclerosis, 225, 83-90, 2012

A novel fluorescent probe with high sensitivity and selective detection of lipid hydroperoxides in cells

Kazunori Yamanaka, Yoshiro Saito, Junji Sakiyama, Yuya Ohuchi, Fumio Oseto, and Noriko Noguchi RSC Advances, 2, 7894 - 7900, 2012

Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes

Hirofumi Misu, Kazuhide Ishikura, Seiichiro Kurita, Yumie Takeshita, Tsuguhito Ota, Yoshiro Saito, Kazuhiko Takahashi, Shuichi Kaneko, and Toshinari Takamura PLoS One, 7, e34952, 2012

Novel compound heterozygous mutations in the SBP2 gene: characteristic clinical manifestations and the implications of GH and triiodothyronine in longitudinal bone growth and maturation

Takashi Hamajima, Yuichi Mushimoto, Hironori Kobayashi, Yoshiro Saito, and Kazumichi Onigata Eur J Endocrinol, 166, 757-764, 2012

Cytoprotective effects of geraniin against peroxynitrite- and peroxyl radical-induced cell death via free radical scavenging activity

Lai Teng Ling, Yoshiro Saito, Uma Devi Palanisamy, Hwee Ming Cheng, and Noriko Noguchi Food Chem, 132, 1899-1907, 2012

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin

Ikuo Hayashi, Sho Takatori, Yasuomi Urano, Yasuyuki Miyake, Junichi Takagi, Mamiko Sakata-Yanagimoto, Hiroko Iwanari, Satoko Osawa, Yuichi Morohashi, Tong Li, Philip C. Wong, Shigeru Chiba, Tatsuhiko Kodama, Takao Hamakubo, Taisuke Tomita, and Takeshi Iwatsubo Oncogene, 31, 787-798, 2012

2011年

Oxidation of DJ-1 Induced by 6-Hydroxydopamine Decreasing Intracellular Glutathione

Akiko Miyama, Yoshiro Saito, Kazunori Yamanaka, Kojiro Hayashi, Takao Hamakubo, and Noriko Noguchi PLoS One, 6, e27883, 2011

Anti-atherogenic effect of laminar shear stress via Nrf2 activation

Wakako Takabe, Eiji Warabi, and Noriko Noguchi Antioxid Redox Signal, 15, 1415-1426, 2011

Redox going with vascular shear stress

Noriko Noguchi and Hanjoong Jo Antioxid Redox Signal, 15, 1367-1368, 2011

24S-Hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis

Kazunori Yamanaka, Yoshiro Saito, Tohru Yamamori, Yasuomi Urano, and Noriko Noguchi J Biol Chem, 286, 24666-24673, 2011

Analyses of marine-derived tocopherol in processed foods containing fish

Naohiro Gotoh, Daisuke Mashimo, Tomiko Oka, Kaori Sekiguchi, Mikiko Tange, Hiroyuki Watanabe, Noriko Noguchi, and Shun Wada Food Chem, 129, 279-283, 2011

α-Tocopheryl phosphate: Uptake, hydrolysis, and antioxidant action in cultured cells and mouse

Keiko Nishio, Noriko Ishida, Yoshiro Saito, Yoko Ogawa-Akazawa, Mototada Shichiri, Yasukazu Yoshida, Yoshihisa Hagihara, Noriko Noguchi, John Chirico, Jeffrey Atkinson, and Etsuo Niki Free Radic Biol Med, 50, 1794-1800, 2011

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction

Akira Kobayashi, Takako Tsukide, Tomohiro Miyasaka, Tomoko Morita, Tatsuya Mizoroki, Yoshiro Saito, Yasuo Ihara, Akihiko Takashima, Noriko Noguchi, Akiyoshi Fukamizu, Yosuke Hirotsu, Makiko Ohtsuji, Fumiki Katsuoka, and Masayuki Yamamoto Genes Cells, 16, 692-703, 2011

Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity

Tohru Yamamori, Ayano Mizobata, Yoshiro Saito, Yasuomi Urano, Osamu Inanami, Kaikobad Irani, and Noriko Noguchi Free Radic Res, 45, 342-350, 2011

Actual ratios of triacylglycerol positional isomers consisting of saturated and highly unsaturated fatty acids in fishes and marine mammals

Nohiro Gotoh, Yumiko Matsumoto, Toshiharu Nagi, Hoyo Mizobe, Ikuko Otake, Kenji Ichioka, Ikuma Kuroda, Hiroyuki Wantanabe, Noriko Noguchi, and Shun Wada Food Chem, 127, 467-472, 2011

Selenoprotein-P is down-regulated in prostate cancer, which results in lack of protection against oxidative damage

Oscar Gonzalez-Moreno, Noemi Boque, Fermin Milagro, Javier Campion, Tobias Endermann, Kazuhiko Takahashi, Yoshiro Saito, Lutz Schomburg, and Alfonso Calvo Prostate, 71, 824-834, 2011

2010年

A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance

Hirofumi Misu, Toshinari Takamura, Hiroaki Takayama, Hiroto Hayashi, Naoto Matsuzawa-Nagata, Seiichiro Kurita, Kazuhide Ishikura, Hitoshi Ando, Yumie Takeshita, Tsuguhito Ota, Masaru Sakurai, Tatsuya Yamashita, Eishiro Mizukoshi, Taro Yamashita, Masao Honda, Ken-ichi Miyamoto, Tetsuya Kubota, Naoto Kubota, Takashi Kadowaki, Han-Jong Kim, In-kyu Lee, Yasuhiko Minokoshi, Yoshiro Saito, Kazuhiko Takahashi, Yoshihiro Yamada, Nobuyuki Takakura, and Shuichi Kaneko Cell Metab, 12, 483-495, 2010

Cytoprotective effect of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function

Yoshiro Saito, Keiko Nishio, Yoko Ogawa Akazawa, Kazunori Yamanaka, Akiko Miyama, Yasukazu Yoshida, Noriko Noguchi, and Etsuo Niki Free Radic Biol Med, 49, 1542-1549, 2010

Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals

Yoko O Akazawa, Yoshiro Saito, Takao Hamakubo, Yoshinori Masuo, Yasukazu Yoshida, Keiko Nishio, Mototada Shichiri, Tomohiro, Miyasaka, Hiroko Iwanari, Yasuhiro Mochizuki, Tatsuhiko Kodama, Noriko Noguchi, and Etsuo Niki Neurosci Lett, 483, 201-205, 2010

Action of 6-amino-3-pyridinols as novel antioxidants against free radicals and oxidative stress in solution, plasma, and cultured cells

Yo Omata, Yoshiro Saito, Yasukazu Yoshida, Byeong-Seon Jeong, Remigiusz Serwa, Tae-gyu Nam, Ned A Porter and Etsuo Niki Free Radic Biol Med, 48, 1358-1365, 2010

Proteomic characterization of the striatum and midbrain treated with 6-hydroxydopamine: Alteration of 58-kDa glucose-regulated protein and C/EBP homologous protein

Yoko Ogawa Akazawa, Yoshiro Saito, Keiko Nishio, Masanori Horie, Tomoya Kinumi, Yoshinori Masuo, Yasukazu Yoshida, Hitoshi Ashida and Etsuo Niki Free Radic Res, 44, 410-421, 2010

Characterization of non-endcapped polymeric ODS column for the separation of triacylglycerol positional isomers

Naohiro Gotoh, Yumiko Matsumoto, Hiromi Yuji, Toshiharu Nagai, Hoyo Mizube, Kenji Ichioka, Ikuma Kuroda, Noriko Noguchi, and Shun Wada J Oleo Sci, 59, 71-79, 2010

Enhanced neointimal hyperplasia and carotid artery remodeling in sequestosome 1 defficient mice

Rika Sugimoto, Eiji Warabi, Satoru Katayanagi, Satoshi Sakai, Junya Uwayama, Toru Yanagawa, Ayaka Watanabe, Harumi Harada, Kiyoshi Kitamura, Noriko Noguchi, Hiroshi Yoshida, Richard C.M. Siow, Giovannni E. Mann, and Tetsuro Ishii J Cell Mol Med, 14, 1546-1554, 2010

An orally applicable Shiga toxin-neutralizer functions in intestine to inhibit the intracellular transport of the toxin

Miho Watanabe-Takahashi, Toshio Sato, Taeko Dohi, Noriko Noguchi, Fumi Kano, Masayuki Murata, Takashi Hamabata, Yasuhiro Natori, and Kiyotaka Nishikawa Infect Immun, 78, 177-183, 2010

Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells

Kenji Ishimoto, Keisuke Tachibana, Ikuko Hanano, Daisuke Yamasaki, Hiroki Nakamura, Megumi Kawai, Yasuomi Urano, Toshiya Tanaka, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, and Takefumi Doi Biochem J, 429, 347-357, 2010

Hydroxyoctadecadienoic acid as a potential biomarker for oxidative stress in patients with chronic hepatitis C

Yasukazu Yoshida, Yasuharu Imai, Yoshiyuki Sawai, Yoshiro Saito, Jiaofei Cao, Kazuto Fukuda, Etsuo Niki J Gastroenterol Hepatol, 25, 107-115, 2010.

2009年

Antioxidant action of sugar-pendant C(60) fullerenes

Masanori Horie, Akiko Fukuhara, Yoshiro Saito, Yasukazu Yoshida , Hiroe Sato, Hiromi Ohi, Makoto Obata, Yuji Mikata, Shigenobu Yano, and Etsuo Niki Bioorg Med Chem Lett, 19, 5902-5904, 2009

Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients

Yoshiro Saito, Takao Hamakubo, Yasukazu Yoshida, Yoko Ogawa, Yasuo Hara, Harutoshi Fujimura, Yasuharu Imai, Hiroko Iwanari, Yasuhiro Mochizuki, Mototada Shichiri, Keiko Nishio, Tomoya Kinumi, Noriko Noguchi, Tatsuhiko Kodama, and Etsuo Niki Neurosci Lett, 465, 1-5, 2009

Dietary marine-derived tocopherol has a higher biological availability in mice relative to alpha-tocopherol

Naohiro Gotoh, Hiroyuki Watanabe, Tomiko Oka, Daisuke Mashimo, Noriko Noguchi, Kazuhiko Hata, and Shun Wada Lipids, 44, 133-143, 2009

Protein Adsorption of Ultrafine Metal Oxide and Its Influence on Cytotoxicity toward Cultured Cells

Masanori Horie, Keiko Nishio, Katsuhide Fujita, Shigehisa Endoh, Arisa Miyauchi, Yoshiro Saito, Hitoshi Iwahashi, Kazuhiro Yamamoto, Hideki Murayama, Hajime Nakano, Naoki Nanashima, Etsuo Niki , and Yasukazu Yoshida Chem Res Toxicol, 22, 543-553, 2009

Assessment of antioxidant capacity of fermented grain food product, Antioxidant Biofactor (AOB), by ORAC method and inhibition of lipid peroxidation

Yo Omata, Yoko Ogawa, Yoshiro Saito, Yasukazu Yoshida, and Etsuo Niki Food Chem, 114, 429-433, 2009

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity

Ikuo Hayashi, Sho Takatori, Yasuomi Urano, Hiroko Iwanari, Noriko Isoo, Satoko Osawa, Maiko A. Fukuda, Tatsuhiko Kodama, Takao Hamakubo, Tong Li, Philip C. Wong, Taisuke Tomita, and Takeshi Iwatsubo J Biol Chem, 284, 27838-27847, 2009

2008年

Regulation of GCL Activity and Cellular Glutathione through Inhibition of ERK Phosphorylation

Zhi-Hua Chen, Yoshiro Saito, Yasukazu Yoshida, Noriko Noguchi, and Etsuo Niki Biofactors, 33, 1-11, 2008

Antioxidant capacity of BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2- dipentylbenzofuran, and uric acid as evaluated by ORAC method and inhibition of lipid peroxidation

Etsuo Niki, Akiko Fukuhara, Yo Omata, Yoshiro Saito, and Yasukazu Yoshida Bioorg Med Chem Lett, 18, 2464-2466, 2008

Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells

Yoshiro Saito, Akiko Fukuhara, Keiko Nishio, Mieko Hayakawa, Yoko Ogawa, Hirokazu Sakamoto, Kenji Fujii, Yasukazu Yoshida, and Etsuo Niki J Nutr Biochem, 20, 350-357, 2008

g-Tocopheryl quinone, not a-tocopheryl quinone, induces adaptive response through up-regulation of cellular glutathione and cysteine availability via activation of ATF4

Yoko Ogawa, Yoshiro Saito, Keiko Nishio, Yasukazu Yoshida, Hitoshi Ashida, and Etsuo Niki Free Radic Res, 42, 674-687, 2008

Induction of adaptive response and enhancement of PC12 cell tolerance by lipopolysaccharide primarily through the upregulation of glutathione S-transferase A3 via Nrf2 activation

Yo Omata, Yoshiro Saito, Katsuhide Fujita, Yoko Ogawa, Keiko Nishio, Yasukazu Yoshida, and Etsuo Niki Free Radic Biol Med, 45, 1437-1445, 2008

Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex

Yasuomi Urano, Hiroshi Watanabe, Stephanie R. Murphy, Yohei Shibuya, Yong Geng, Andrew A. Peden, Catherine C.Y. Chang, and Ta-Yuan Chang Proc Natl Acad Sci USA, 105, 16513-16518, 2008

Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults

Keiko Nishio, Akiko Fukuhara, Yo Omata, Yoshiro Saito, Shuuhei Yamaguchi, Hisatoyo Kato, Yasukazu Yoshida, and Etsuo Niki Bioorg Medicin Chem, 16, 10332-10337, 2008

Assessment of antioxidant capacity of fermented grain food product, Antioxidant Biofactor (AOB), by ORAC method and inhibition of lipid peroxidation

Yo Omata, Yoko Ogawa, Yoshiro Saito, Yasukazu Yoshida, and Etsuo Niki Food Chem, 114, 429-433, 2009

Assessment of Radical Scavenging Capacity and Lipid Peroxidation Inhibiting Capacity of Antioxidant

Etsuo Niki, Yo Omata, Akiko Fukuhara, Yoshiro Saito, and Yasukazu Yoshida J Agricult Food Chem, 56, 8255-8260, 2008

Simple Assessment of Radical Scavenging Capacity of Beverages

Yo Omata, Yoshiro Saito, Yasukazu Yoshida, and Etsuo Niki J Agricult Food Chem, 56, 3386-3390, 2008

Antioxidant capacity of BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran, and uric acid as evaluated by ORAC method and inhibition of lipid peroxidation

Etsuo Niki, Akiko Fukuhara, Yo Omata, Yoshiro Saito, and Yasukazu Yoshida Bioorg Medic Chem Lett, 18, 2464-2466